个人简介
新药创制与绿色合成研究所 所长
医药分子科学与制剂工程工信部重点实验室 副主任
招生硕博专业：化学工程与技术/制药工程/化学/药学
研究兴趣：重大疾病的相关创新药物研发
个人主页
//www.x-mol.com/groups/ljh_bit
研究领域和方向
针对临床未满足的重大疾病需求，如超级耐药菌感染、关节炎、胰腺炎、败血症、抑郁症、脑部外创伤、老年痴呆症等，从具有成药性优势的天然骨架（如大环内酯、小檗碱、血根碱、紫檀芪、甘草次酸、碳苷黄酮等）出发，利用现代化学生物学、蛋白质组学、结构生物学以及人工智能计算机寻靶等手段寻找新的靶标或者作用模式，合成生物学或有机化学合成新分子，突破现有的治疗手段的局限性。通过迭代药物设计和改造结构，提高提高先导化合物的生物活性和类药性，同时，在化学和生物学的交叉层面中阐明分子作用机制，最终获得针对重大疾病模型的具有体外、体内活性的临床候选化合物。
教育背景
1999.9~2004.3 北京理工大学材料科学与工程皇冠体育 ，博士（国防科工委优秀毕业生） 1995.9~1999.7 北京理工大学化工与材料皇冠体育 ，学士（北京市优秀毕业生）
工作履历
2004.4~至今 北京理工大学生命皇冠体育 /皇冠体育 讲师/副教授/教授 2019.7~2020.8 College of Pharmacy, University of Minnesota, Visiting Professor 2010.4~2011.4 College of Pharmacy, Purdue University, Visiting Professor
研究成果
在药物化学、化学生物学、有机化学、计算机药物设计方向发表研究论文，包括Nature Chemical Biology, Cell Discovery, Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, Bioorganic Chemistry, Current Medicinal Chemistry, Current Topics in Medicinal Chemistry, Bioorganic & Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters、Journal of Antibiotics等。论文清单见 ORCID: //orcid.org/0000-0003-1309-8521 代表性论文： 1.Liu Xing-Zhou#, Du Xiao-Yu#, Xie Wei-Song#, Ding Jing#, Zhu Min-Zhen, Feng Zi-Qiang, Wang Hao, Feng Yue*, Yu Ming-Jia*, Liu Si-Meng, Liu Wen-Tian, Zhu Xin-Hong*, Liang Jian-Hua*. Redesigning Berberines and Sanguinarines to Target Soluble Epoxide Hydrolase for Enhanced Anti-Inflammatory Efficacy. Journal of Medicinal Chemistry, 2024, 67(24): 22168−22190, DOI: 10.1021/acs.jmedchem.4c02202 2.Liu Qian #, Wang Yi-Xin #, Ge Zi-Hao #, Zhu Min-Zhen #, Ding Jing, Wang Hao, Liu Si-Meng, Liu Rui-Chen, Li Chun, Yu Ming-Jia, Feng Yue *, Zhu Xin-Hong *, Liang Jian-Hua *. Discovery of glycosidated glycyrrhetinic acid derivatives: natural product-based soluble epoxide hydrolase inhibitors. European Journal of Medicinal Chemistry, 2024, 280: 116937, DOI: 10.1016/j.ejmech.2024.116937 3.Ding Jing, Zhu Min-Zhen, Liu Si-Meng, Liu Rui-Chen, Xu Shuo, Shehzadi Kiran, Ma Hong-Le, Yu Ming-Jia*, Zhu Xin-Hong*, Liang Jian-Hua*. Discovery of Orally Active Phenylquinoline-based Soluble Epoxide Hydrolase Inhibitors with Anti-inflammatory and Analgesic Activity. Journal of Medicinal Chemistry, 2024, 67(20):18412-18447, DOI：10.1021/acs.jmedchem.4c01766 4.Zhang Na #, Liu Wen-Tian #, Cui Xin-Yi, Liu Si-Meng, Ma Cong-Xuan, Liang Jian-Hua *. Design and Structure-Activity Relationships of Ether-linked Alkylides: Hybrids of 3-O-Descladinosyl Macrolides and Quinolone Motifs. Bioorganic Chemistry. 2024, 151，107712. DOI: 10.1016/j.bioorg.2024.107712 5.Aleksandrova Elena V. #, Ma Cong-Xuan #, Klepacki Dorota #, Alizadeh Faezeh, Vázquez-Laslop Nora, Liang Jian-Hua *, Polikanov Yury S. *, Mankin Alexander S. *. Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms. Nature Chemical Biology, 2024, 20; 1680–1690. DOI: 10.1038/s41589-024-01685-3 (News & Views: Mohamed I. Barmada & Graeme L. Conn. Evading resistance at the double. Nature Chemical Biology, 2024, 20; 1555–1556) 6.Ma Cong-Xuan #, Li Ye #, Liu Wen-Tian, Li Yun, Zhao Fei, Lian Xiao-Tian, Ding Jing, Liu Si-Meng, Liu Xie-Peng, Fan Bing-Zhi, Liu Li-Yong, Xue Feng, Li Jian, Zhang Jue-Ru, Xue Zhao, Pei Xiao-Tong, Lin Jin-Zhong *, Liang Jian-Hua * Synthetic macrolides overcoming MLSBK-resistant pathogens. Cell Discovery, 2024, 10. 75. DOI : 10.1038/s41421-024-00702-y 7.Ma Cong-Xuan, Liu Wen-Tian, Li Xue-Meng, Ding Jing, Liu Si-Meng, Xue Feng, Li Yun,* Liang Jian-Hua.* Design, synthesis and structure-activity relationships of novel non-ketolides: 9-Oxime clarithromycin featured with seven-to thirteen-atom-length diamine linkers at 3-OH. European Journal of Medicinal Chemistry, 2024, 276, 116630. DOI: 10.1016/j.ejmech.2024.116630 8.Feng Zi-Qiang, # Ding Jing, # Zhu Min-Zhen, # Xie Wei-Song, Liu Rui-Chen, Liu Si-Si, Liu Si-Meng, Yu Ming-Jia, * Zhu Xin-Hong * Liang Jian-Hua *. Discovery of a novel lead characterized by a stilbene-extended scaffold against sepsis as soluble epoxide hydrolase inhibitors. European Journal of Medicinal Chemistry, 2024, 266, 116113. DOI：10.1016/j.ejmech.2023.116113 9.Zhang Heao, Xiang Lin, Yang Liang, Wu Si, Liu Sisi, Zhao Juan, Song Da, Ma Congxuan, Ni Junjun, Quan Zhenzhen, Liang Jianhua*, Qing Hong*. WS6 induces adult hippocampal neurogenesis in correlation to its antidepressant effect on the alleviation of depressive-like behaviors of rats. Neuroscience, 2021, 473, 119-129 10.Liang Jian-Hua*#, Yang Liang#, Wu Si#, Liu Si-Si, Cushman Mark, Tian Jing, Li Nuo-Min, Yang Qing-Hu, Zhang He-Ao, Qiu Yun-Jie, Xiang Lin, Ma Cong-Xuan, Li Xue-Meng, Qing Hong*. Discovery of Efficient Stimulators for Adult Hippocampal Neurogenesis Based on Scaffolds in Dragon's Blood. European Journal of Medicinal Chemistry, 2017, 136, 382-392. （DOI：10.1016/j.ejmech.2017.05.025）